Mechanisms of Antimicrobial Resistance

Antimicrobial resistance occurs when microorganisms adapt and become less responsive to treatments, making infections harder to control. This resistance develops through various mechanisms, including genetic mutation and the transfer of resistance genes between microbes. Common strategies involve altering drug targets, producing enzymes that deactivate medications, and reducing drug uptake. Biofilm formation also shields bacteria, enhancing their defense. These changes reduce the effectiveness of standard therapies, leading to prolonged illness and increased healthcare challenges. Understanding these mechanisms is vital for developing new treatment approaches and preserving the effectiveness of current antimicrobial agents in managing bacterial and infectious diseases.

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