Antibiotics and Bacterial Infections

Genetics and Proteomics of antimicrobial

Bacteria can acquire antimicrobial genes from other bacteria in several ways. By undergoing an easy mating process called "conjugation," bacteria can transfer genetic material, including genes encoding resistance to antibiotics (found on plasmids and transposons) from one bacterium to a different . Antibiotic resistance genes are identified in diverse environments including soil, gull feces and, increasingly, within the human gut microbiota. Scientists have applied a variety of approaches to detect antimicrobial genes in environmental or non-clinical microbiomes, all of which have their own inherent strengths/limitations.

Proteomic studies have improved our understanding of the microbial world. the foremost recent advances during this field have helped us to explore aspects beyond genomics. Proteomics has also advanced our knowledge of mechanisms of bacterial virulence and a few important aspects of how bacteria interact with human cells and, thus, of the pathogenesis of infectious diseases. we've used proteomic technology to elucidate the complex cellular responses of Bacillus subtilis to antimicrobial compounds belonging to classical and emerging antibiotic classes